• Formula 18 Reinvigorator

Reinvigorator

  • Summary
  • Suggested Use

An advanced daily supplement to boost cellular repair, optimize metabolism and increase energy production.

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Product Details

Unique Features

  • Aids cellular repair
  • Enhances energy production
  • Helps metabolic optimization
  • Promotes healthy aging
  • Supports healthy sleep cycles

Vegetarian Friendly

Preservative Free

Product Comparison

Herbalmax Reinvigorator has been carefully formulated according to years of research on longevity and aging. The main ingredient in Reinvigorator is Nicotinamide Mononucleotide (NMN). NMN is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme which is involved in thousands of cellular processes. Research has shown that NAD+ decreases with age and this decrease is involved in age related pathology and various diseases.

NAD+ Levels decline with age

Studies have shown that NAD+ levels decrease with age. Studies in both mouse models and human subjects have demonstrated age-related decreases in circulating NAD+. NAD+ is involved in many cellular processes, including fatty acid oxidation, insulin secretion and lipid metabolism. Dysfunctions in these and other NAD+ dependent cellular functions are associated with frailty and pathophysiologies which become more common with advanced age.

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The observed correlation between NAD+ levels and aging adds weight to the idea that NAD+ may play a role in cell senescence and longevity.

NAD+ Precursor Supplementation Increases Lifespan

Studies in mouse models have shown that supplementation with NMN can increase lifespan, decrease and age-related frailty. This is likely due to NAD+ being a coenzyme for the sirtuin family of proteins, which can activate cellular repair pathways and which have shown to be involved in increasing lifespan and healthspan.

“The observed correlation between NAD+ levels and aging adds weight to the idea that NAD+ may play a role in cell senescence and longevity”

“Maintenance of intracellular NAD+ may therefore be beneficial in counteracting at least some of the age-related cellular degenerative processes.”

NMN Supplementation and Type 2 Diabetic mice

Supplementing diabetic mice with NMN was able to ameliorate Type 2 Diabetes-associated pathophysiologies. Mice given NMN displayed increased insulin sensitivity, decreased blood sugar and overall improvements in metabolic health markers.

“NAD+ biosynthesis is compromised by HFD and aging, contributing to the pathogenesis of type 2 diabetes.”

“promoting NAD+ biosynthesis by administering NMN, a key NAD+ intermediate, can be an effective intervention to treat the pathophysiology of diet- and age-induced Type 2 Diabetes. “

NAD Supplementation and Alzheimer’s mouse models

Studies in Alzheimer’s model transgenic mice have shown significant improvement in symptoms with NMN treatment. Mice treated with NMN showed improved memory, cognitive function as well as a decrease in beta-amyloid plaques in brain tissue.

“The data prove that NMN treatment greatly reduces multiple Alzheimer’s-disease-associated pathological characteristics,”

“In summary, this study provides essential preclinical evidences that NMN takes effects in reversing cognitive deficits and substantially lowering the burden of amyloid plaque, neuroinflammation, cerebral amyloid-β concentrations, and loss of synapse in middle-aged ADTg mice.”

NMN and Vascular Health in mice

Arterial stiffening is associated with advanced age and is a major contributor age-associated heart disease. In addition to being associated with heart problems, stiffening of arteries has been linked to cognitive impairments, metabolic disorders and age-related muscle loss. Treating old mice with NMN significantly improved arterial health and reduced arterial stiffness compared to untreated old mice.

“The results of this study provide the first evidence that oral supplementation with NMN represents a novel strategy for combating arterial aging and its pathological sequelae.”

Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. ;7(7):e42357. doi:10.1371/journal.pone.0042357de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522–530. doi:10.1111/acel.12461Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528–536. doi:10.1016/j.cmet.2011.08.014Yao Z, Yang W, Gao Z, Jia P, Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neuroscience Letters. 2017. 647:133-140. doi: 10.1016/j.neulet.2017.03.027

Ingredients

Herbalmax Proprietary Blend

β-Nicotinamide Mononucleotide
Pterostilbene
Extracts from Epimedium Sagittatum
Acai Berry and Notoginseing

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*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

Reviews

good

Joanna Lee on June 15, 2019
very useful